肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. x3#:C=  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast
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complexity of cancer phenotypes and genotypes into a provisional set of underly- Q_!tn*  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have GYiL}itD=3  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- Lk@+iHf  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- :A!EjIL`#  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate 1#7|au%:)  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added rl~Rb
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to the roster of functionally important cell types in the tumor microenvironment.