首都医科大学 x}O J~Yk]
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生物化学 r%`3*<ALV)
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2015首都医科大学博士入学考试-生物化学回忆版 UW{C`^?=B
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一、名词解释(应该是5个,但是记不清是哪5个了) 9T<k|b[6
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1.chaperon 2.motif 3.allosteric enzyme 4.ribozyme 5.gluconeogenesis 6.sernicon servativereplication O:#/To'
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二、选择题(很多题记不太清楚了,细节问题请包容) O{EbL5p
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1.Which of the followingstatements concerning protein domains is true? %U9f`q
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A.they are examples ofstructural motifs n]3Z~HoZ
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Dn^B1^
B.large polypeptide may beorganized into struoturally close but functionally independent units g+-^6UG
w^[:wzF0
C.the consist of separatepoly peptide chains(subunits) 5.lg*vh
Q!h+1fb
D.they have been found onlyin prokaryotic proteins xj Jo
WB
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2.Prion disease aregenerally believed to a associated with Q>TNzh
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A.infection by a RNA vins B.infection by DNA C.infection by protein D.infection by mRNA 0"iQHi
0SJ(Ln`0K
3.The secondary structureof transfer RNA is <4N E)!#
qKs"L^b
A.described as double helix B.described as reversed “L” C.described as cloverleaf D.present only ineukaryotic cells sr
H.$Y;~
ZpZoOdjslV
4.In competitive inhibiyion y .a)M?3
jK2gc^"t
A.Km not change,Vmax not change B.Km rise, Vmaxnot change C.Km not change,Vmax rise D.Km rise, Vmaxrise 0&c<1;
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5.The part og the RNApolymerase noloenzyme that initiates binding to DNA is called the +xNq8yS
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A.sigma factor B.intron C.ribosomal RNA D.core enzyme cpx:4R,
0VIR=Pbp
6.Sunlight can damage DNAby DOq"=R+
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A.making apyrimidinic sites B.causing spontaneousdeamination of bases D+7[2$:z
la`f@~Bbr1
C.forming pyrimidinedimmers D.alkylating DNA H
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7.Which is therate-limiting enzyme, inregulation of the pentose phosphate pathway? ![m6$G{y
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A.hexokinase B.6-phosphofructokinace-1 C.Clucose-6-phosphatedehydrogenase D.pyrurate dehydrogenase
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8.Transcription is theprocess in which 8B6-f:
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A.protein is synthesized from DNA B.DNA is replicated aX.//T:':?
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C.RNA is synthesized from protein D.ENA is synthesized fromDNA m5cRHo<9Y
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9.Which of the following isa sis-acting element? .v['INK9
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A.RNA polymerase B.Enhancer C.transcriptionfactor I D.structural gene ME*A6/h
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10.The protein that canbind to RNA and prevent the trascription is called k!d<2Qp W
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A.inducer B.repressor protein C.cis-acting element D.positive regulatoryproteins <A&Zl&^1
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11.蛋白质吸收紫外光的大小取决于 Kr+#)S
G'{&*]Z\:
A.脂肪族氨基酸含量 B.酸性氨基酸含量 C.芳香族氨基酸含量 D. 蛋氨酸含量 EEiWIf&S,
1tl qw
12.DNA变性是指 dyB@qh~H
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A.分子中磷酸二酯键断裂 B.多核苷酸链解裂 C.DNA分子由超螺旋变为双键双螺旋 D.互补碱基之间氢键断裂 jwhe
JG
imyfki $B
13.关于关键酶的叙述哪项错误? ow#8oUf=
E|W7IgS
A.关键酶常是变构酶 B.关键酶常位于代谢途径的起始或分叉部位 y8dOx=c
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C.关键酶是共价修饰酶 D.关键酶活性最高 _.SpU`>/f
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14.下列哪个反应是三羧酸循环中的底物水平磷酸化反应: Wl]XOUZ
CW+g
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A.异柠檬酸—α-酮戊二酸 B.琥珀酰COA—琥珀酸 C.琥珀酸—延胡索酸 D.延胡索酸—苹果酸 2%)~E50U
=]1g*~%
15.体内贮存脂肪主要代谢来自 IH.EvierJ
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A.酮体 B.葡萄糖 C.脂肪酸 D.生糖氨基酸 u/FC\xJc
..=lM:13|
16.人体内CO2生成方式是: ,Qj\_vr@
>S%}HSPKq
A.O2与C直接合成 B.O2与CO结合 C.有机酸的脱羧 D.一碳单位与O2结合 i*mI-l
=nlj|S ~3
17.飘零核苷酸从头合成时生成的重要代谢中间物是: T#HF!GH]
(Z8wMy&:
A.GMP B.AMP C.TMP D.GTP ?<^^.Si
qJR8fQ
18.细胞核中分布的酶主要是关于催化代谢的: boZ/*+t
r>G||/Z
A.糖代 B.甘油三酯代 C.蛋白质代 D.核糖代谢 &uI33=
JY_!G
19.外显子是: Bo
??1y
e'|c59E
A.基因突变的表现 B.DNA被水解断裂片段 C.转录模板链 D.真核生物的编码序列 ]NKz5[9D
'lmjZ{k
20.基因表达调控的基本控制点是: P#"_H}qC*
_,w*Rv5=
A.基因结构活化 B.转录起始 C.转录后加工 D.蛋白质的翻译及译后加工 Ad4-aWH
Ld=6'C8ud
21.从头合成TMP与UMP的共同原料是: )2r_EO@3HP
VYrs4IFT$
A.氨甲酰磷酸 B.磷酸核糖焦磷糖 C.甘氨酰胺核苷酸 D.甲酰甘氨核苷酸 4ZB]n,pfT
>uE<-klv
22.不能氧化酮体的组织是: >Fc=F#tA9
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A.心脏 B.肝脏 C.脑 D.肾 5e2yJ R
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23.三羧酸循环的限速酶是: =-G4BQ
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A.异柠檬酸脱氢酶 B.顺乌头酸酶 C.α-酮戊二酸脱氢酶 D.苹果酸脱氢酶 ,Uy~O(Ft
\]Rmq_O
24.脂肪酸合成中的供氧体是: *k 0;R[IAV
U)1hC^[!
A.FADH2 B.NADH+H+ C.NADPH+H+ D.FMNH2 q4Y'yp`?K;
Gn<e&|4>i}
25.血浆中胆固醇酯化需要: oB+@05m8
mQ\oR|
A.脑磷脂 B.卵磷脂 C.乙酰COA D.酯酰COA ' &Nv|v\V
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26.哪个是糖酵途径中的限速酶: RI]x=
q&,uJo
A.6-磷酸葡萄糖酶 B.6-磷酸果糖激酶-1 C.3-磷酸甘油醛脱氢酶 D.磷酸甘油 ,km`-6.2?
q{7+N1
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27.肌肉中氨基酸脱氢的主要方式 +b{tk=Q:
6Q`7>l.|?
A.联合脱氢作用 B.嘌呤核苷酸循环 C.转氨作用 D.L-谷氨酸氧化脱氢作用 p0HcuB)Y
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28.体内转化一碳单位的载体是: ?<soX8_1
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A.叶酸 B.COASH C.四氢叶酸 D.FAD )lVplAhZD
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29.合成卵磷脂时所需的活性胆碱是: $HV`bJ5!L*
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A.CDP-胆碱 B.CDP-胆碱(?不记得了) C.GDP-胆碱 D.ADP-胆碱 cA`X(Am6]g
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30.常见的酸性氨基酸是: 6Ou[t6
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A.Asp和Gln B.Asp和Gly C.Asp和Glu D.Ary和Lys lAx8m't}6
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31.鸟氨酸循环中需要N-乙酰谷氨酸作为激活剂的酶是: -)E6{
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A.鸟氨酸氨基甲酰转移酶 B.氨基甲酰磷酸合成酶 C.精氨酸代琥珀酸裂解酶 D.精氨酸酶 Tc;j)_C)
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