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2015首都医科大学博士入学考试-生物化学回忆版 bz2ztH9 n
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一、名词解释(应该是5个,但是记不清是哪5个了) ]7F=u!/`<C
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1.chaperon 2.motif 3.allosteric enzyme 4.ribozyme 5.gluconeogenesis 6.sernicon servativereplication $m%fwB
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二、选择题(很多题记不太清楚了,细节问题请包容) NMa} {*sQ
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1.Which of the followingstatements concerning protein domains is true? "$Z= %.3Q
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A.they are examples ofstructural motifs EyD=q! ZVZ
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B.large polypeptide may beorganized into struoturally close but functionally independent units @uqd.Q
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C.the consist of separatepoly peptide chains(subunits) /og=IF2:
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D.they have been found onlyin prokaryotic proteins w(*vj
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2.Prion disease aregenerally believed to a associated with BOb">6C
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A.infection by a RNA vins B.infection by DNA C.infection by protein D.infection by mRNA c?f4Q,%|
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3.The secondary structureof transfer RNA is (Y.k8";)`
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A.described as double helix B.described as reversed “L” C.described as cloverleaf D.present only ineukaryotic cells ITE{@1
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4.In competitive inhibiyion U2tV4_ e
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A.Km not change,Vmax not change B.Km rise, Vmaxnot change C.Km not change,Vmax rise D.Km rise, Vmaxrise
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5.The part og the RNApolymerase noloenzyme that initiates binding to DNA is called the MnsJEvn/
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A.sigma factor B.intron C.ribosomal RNA D.core enzyme fy>{QC\
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6.Sunlight can damage DNAby VZp5)-!\
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A.making apyrimidinic sites B.causing spontaneousdeamination of bases Dzpq_F!;V
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C.forming pyrimidinedimmers D.alkylating DNA ^]>O;iB?
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7.Which is therate-limiting enzyme, inregulation of the pentose phosphate pathway? FZ{h?#2?
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A.hexokinase B.6-phosphofructokinace-1 C.Clucose-6-phosphatedehydrogenase D.pyrurate dehydrogenase zq3\}9
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8.Transcription is theprocess in which :(E@Gf
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A.protein is synthesized from DNA B.DNA is replicated |0&IXOW"XF
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C.RNA is synthesized from protein D.ENA is synthesized fromDNA -vAC"8)S
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9.Which of the following isa sis-acting element? #>a\>iKQ2q
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A.RNA polymerase B.Enhancer C.transcriptionfactor I D.structural gene o3XvRj
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10.The protein that canbind to RNA and prevent the trascription is called +N]J5Ve-`t
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A.inducer B.repressor protein C.cis-acting element D.positive regulatoryproteins (=FRmdeYl1
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11.蛋白质吸收紫外光的大小取决于 {Ea
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A.脂肪族氨基酸含量 B.酸性氨基酸含量 C.芳香族氨基酸含量 D. 蛋氨酸含量 \Zb;'eDv
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12.DNA变性是指 3h]g}&k
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A.分子中磷酸二酯键断裂 B.多核苷酸链解裂 C.DNA分子由超螺旋变为双键双螺旋 D.互补碱基之间氢键断裂 Q1lyj7c#x
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13.关于关键酶的叙述哪项错误? S0$8@"~=
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A.关键酶常是变构酶 B.关键酶常位于代谢途径的起始或分叉部位 "mo?*
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C.关键酶是共价修饰酶 D.关键酶活性最高 >:SHV W
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14.下列哪个反应是三羧酸循环中的底物水平磷酸化反应: L]7=?vN=8
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A.异柠檬酸—α-酮戊二酸 B.琥珀酰COA—琥珀酸 C.琥珀酸—延胡索酸 D.延胡索酸—苹果酸 Z
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15.体内贮存脂肪主要代谢来自 5#6|j?_a
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A.酮体 B.葡萄糖 C.脂肪酸 D.生糖氨基酸 g_E$=j92v
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16.人体内CO2生成方式是: 3l]lwV
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A.O2与C直接合成 B.O2与CO结合 C.有机酸的脱羧 D.一碳单位与O2结合 Xc++b|k
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17.飘零核苷酸从头合成时生成的重要代谢中间物是: alJ)^OSIe
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A.GMP B.AMP C.TMP D.GTP [>3./YH`
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18.细胞核中分布的酶主要是关于催化代谢的: ,i NXK
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A.糖代 B.甘油三酯代 C.蛋白质代 D.核糖代谢 e)IzQ7Zex
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19.外显子是: sFKX-S~:
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A.基因突变的表现 B.DNA被水解断裂片段 C.转录模板链 D.真核生物的编码序列 ';Ea?ID
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20.基因表达调控的基本控制点是: &A/]pi-\
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A.基因结构活化 B.转录起始 C.转录后加工 D.蛋白质的翻译及译后加工 u]wZQl#-
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21.从头合成TMP与UMP的共同原料是: m,28u3@r
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A.氨甲酰磷酸 B.磷酸核糖焦磷糖 C.甘氨酰胺核苷酸 D.甲酰甘氨核苷酸 \&:nFb%=
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22.不能氧化酮体的组织是: @n/\L<