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要求简练,精确 p)YI8nW
Compassionate use of bevacizumab (Avastin) in children and young adults with !v?WyGbUg
refractory or recurrent solid tumors. XFJz\'{
Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma 7Ug^aA
xenografts results in improved delivery and efficacy of systemically administered tJ9-8ZT*
chemotherapy. bTJ l
Proteomics Approaches to the Systems Biology of Cardiovascular Diseases Q'R*a(pm
Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis.
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Lack of early bevacizumab-related skeletal radiographic changes in children with p8|u 0/;k
neuroblastoma. #:M <<gk
Interleukin-4 activates androgen receptor through CBP/p300 !6pE0(V^+4
Trisomy 8 in an allogeneic stem cell transplant recipient representative of a bY!1t}ALh
donor-derived constitutional abnormality. TV[@!E a
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy (GB*+@
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase- DWmViuZmL
High-dose conformal RT improves tumor control in patients with prostate cancer u3])_oj=
Vitamin D concentration does not affect the risk of prostate cancer j
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Liver resection with salvage transplantation for hepatocellular carcinoma `2PvE4]%p
The impact of histopathologic diagnosis on the proper management of testis neoplasms o@W:PmKW
Prostate stem cell antigen is associated with diffuse-type gastric cancer dH_g:ocA
Multiple myeloma: high-risk immunophenotypes identified [a!*m<
Increased c-kit expression predicts poor outcome in acute myeloid leukemia 29kR7[k
Global Analysis of the Meiotic Crossover Landscape PsCr[\Ul
Serum Response Factor Is Required for Sprouting Angiogenesis and Vascular Integrity y_}jf,b4
Integrin Trafficking Regulated by Rab21 Is Necessary for Cytokinesis oa2v/P1`
Reduced Translocation of Nascent Prion Protein During ER Stress Contributes to L6n<h
Neurodegeneration _t.Ub:
Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: (c|Ry[$|
Results of the randomized, double-blind, placebo-controlled INEF study. W
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Global experiences with vardenafil in men with erectile dysfunction and underlying 09sdt;V Q
conditions. E-"b":@:
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Noninvasive cardiac imaging: implications for risk assessment in adolescents and young E)]RQ~jY?
adults. B0$.oavC
Transforming growth factor beta1 T29C gene polymorphism and hypertension: <0!)}O
Relationship with cardiovascular and renal damage. E%vT(Kz
A comparison of hormone therapies on the urinary excretion of prostacyclin and d6+{^v$#
thromboxane A2. %W,V~kb
Repair of an infected aortic aneurysm using an aortic allograft and a venous autograft: :,1kSM%r
Report of a case. Q/ ^a(
Circulating Leptin and Stress-induced Cardiovascular Activity in Humans. !B:wzb_
Effects of aspirin dose on ischaemic events and bleeding after percutaneous coronary Rn5{s3?F~2
intervention: insights from the PCI-CURE study. F |^tRL-
Long-term cardiovascular outcomes following ischemic heart disease in patients with and U2
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without peripheral vascular disease. XG;Dj<Dm
Reduced renal function and sleep-disordered breathing in community-dwelling elderly f&88N<)
men. GRj#1OqL
Intracoronary pharmacotherapy in the management of coronary microvascular @lTd,V5f
dysfunction. bm#/ KT_8
Inhibition of platelet aggregation by combined therapy with aspirin and cilostazol after PIZK*Lop
off-pump coronary artery bypass surgery. #s3R4@{
Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice :BpXi|n;
Abstract 要求简洁,连贯 MVOWJaT(Aq
The acquisition of metastatic ability by tumor cells is considered a late event in the /j;HM[
evolution of malignant tumors. We report that untransformed mouse mammary cells that #v}pn2g%>
have been engineered to express the inducible oncogenic transgenes MYC and KrasD12, or ,B,:$G<
polyoma middle T, and introduced into the systemic circulation of a mouse can bypass v#b(
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transformation at the primary site and develop into metastatic pulmonary lesions upon ` <IaQY
immediate or delayed oncogene induction. Therefore, previously untransformed '-M9v3itC
mammary cells may establish residence in the lung once they have entered the ~R
C\
bloodstream and may assume malignant growth upon oncogene activation. Mammary "eZ~]m}L0
cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in \CVrLn;}
the lungs but did not form ectopic tumors. KSxZ4Y
Almost two decades after CFTR was identified as the gene responsible for cystic fibrosis Z^6qxZJ7
(CF), we still lack answers to many questions about the pathogenesis of the disease, and it ]3I@5 }5%
remains incurable. Mice with a disrupted CFTR gene have greatly facilitated CF studies, rB}2F*eT
but the mutant mice do not develop the characteristic manifestations of human CF, mae@
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including abnormalities of the pancreas, lung, intestine, liver, and other organs. Because $n_ax\15
pigs share many anatomical and physiological features with humans, we generated pigs Z:.*fs5
with a targeted disruption of both CFTR alleles. Newborn pigs lacking CFTR exhibited RKD$'UWX
defective chloride transport and developed meconium ileus, exocrine pancreatic <Xb$YB-c
destruction, and focal biliary cirrhosis, replicating abnormalities seen in newborn humans jYE
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with CF. The pig model may provide opportunities to address persistent questions about k293wS
CF pathogenesis and accelerate discovery of strategies for prevention and treatment. M=#g_*d
Variable lymphocyte receptors (VLRs) rather than antibodies play the primary role in Q(/F7"m
recognition of antigens in the adaptive immune system of jawless vertebrates. r;SOAucX
Combinatorial assembly of leucine-rich repeat (LRR) gene segments achieves the 2c%b
required repertoire for antigen recognition. We have determined a crystal structure for a &FY7
D<
VLR-antigen complex, VLR RBC36 in complex with the H-antigen trisaccharide from :aWC6"ik-W
human blood type O erythrocytes, at 1.67 angstrom resolution. RBC36 binds the )Ag{S[yZ
H-trisaccharide on the concave surface of the LRR modules of the solenoid structure e~PAi8B5
where three key hydrophilic residues, multiple van der Waals interactions, and the highly *nlDN4Y[
variable insert of the carboxyl-terminal LRR module determine antigen recognition and } bm ^`QY
specificity. The concave surface assembled from the most highly variable regions of the BoP,MpF
LRRs, along with diversity in the sequence and length of the highly variable insert, can M+-1/vR *@
account for the recognition of diverse antigens by VLRs. m4,inA:o
A 51-year-old man with a diagnosis of myelodysplasia and non-Hodgkin's lymphoma +%?\#E QJ
underwent an unmatched allogenic bone marrow transplantation and was treated \
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posttransplant with chronic immunosuppressive medication. Eight months following l^R1XBP
transplantation, he presented with progressive dysarthria, cognitive and visual decline. ].
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Evaluation included brain magnetic resonance (MR) imaging demonstrating multifocal J
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areas of increased T2 and FLAIR (fluid attenuated inversion recovery) signals involving C~R,,
the left frontal, parietal, and occipital lobes. The MR lesions demonstrated diffuse HleMzykF
increased signal on DWI (diffusion-weighted images) and normal to low signal on ADC V?-SvQIk1
(apparent diffusion coefficients). Contrast-enhanced T1 images were unremarkable. >DoP2]
Lumbar puncture revealed a mild elevation in cerebrospinal fluid (CSF) protein. CSF li9>zjz
PCR assay for viral DNA fragments were negative on two occasions. Serum serology for MR/gLm
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HIV was negative as well. A brain biopsy was subsequently performed. The clinical and pZ5eGA=
neuroimaging differential diagnoses as well as neuropathologic correlation are presented. 7uq^TO>9f
In vitro-generated mesenchymal stem cells (MSCs) initially attracted interest for their #]z_pp:
ability to undergo differentiation toward cells of different lineages. =`.OKUAn
These results suggested that ZiC~8p_f
However, there are still obstacles in cBQ+`DXn5c
The major challenge for successful drug development is identifying delivery strategies g[(Eh?]Sc
that can be translated to the clinic. -;iCe7|Twf
This review will discuss progress in developing and testing small RNAi-based drugs and -`,Fe3
potential obstacles. kHd`k.nW
This review highlights what 'M,O(utGv
In addition, there are indications that /ommM
Proper consideration of all of these issues will be necessary in d$:LUxM#
These studies provide 4P^CqD&i
This paper presents the potential applications and the hurdles facing anti-HCV siRNA k1~? }+<e
drugs. >*WT[UU
The present review provides insight into the feasible therapeutic strategies of siRNA 1!Afq}|
technology, and its potential for silencing genes associated with HCV disease. @0-vf>e3-
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A basic problem in the design of xx is presented by the choice of a xx rate for the 6Cgc-KNbk
measurement of experimental variables.
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This paper examines a new measure of xx in xx based on fuzzy mathematics which ftD(ed
overcomes the difficulties found in other xx measures.
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This paper describes a system for the analysis of the xx. ^J)0i_RS
The method involves the construction of xx from fuzzy relations. m^>v~Q~~
The procedure is useful in analyzing how groups reach a decision. dZCnQ IS
The technique used is to employ a newly developed and versatile xx algorithms. LvNulMEK
The usefulness of xx is also considered. #Ve@D@d[
A brief methodology used in xx is discussed. ]E^)d|_
The analysis is useful in xx and xx problem. d fSj= 4
A model is developed for a xx analysis using fuzzy matrices. OJD!Ar8Q
Algorithms to combine these estimates and produce a xx are presented and justified. }z5u^_-m
The use of the method is discussed and an example is given. 5
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Results of an experimental applications of this xx analysis procedure are given to }J $\<ZT
illustrate the proposed technique. wY3|5kbDj
This paper analyses problems in h}Lrp r2r
This paper outlines the functions carried out by ... 395`Wkv
This paper includes an illustration of the ... y7x*:xR[
This paper provides an overview and information useful for approaching \|CuTb;0
Emphasis is placed on the construction of a criterion function by which the xx in +asO4'r
achieving a hierarchical system of objectives are evaluated. !,R=6b$E5
The main emphasis is placed on the problem of xx >fzFNcO*
Our proposed model is verified through experimental study. DB(!*6#?
The experimental results reveal interesting examples of fuzzy phases of : xx,xx ^O,r8K{1n
The compatibility of a project in terms of cost, and xx are likewise represented by *d9RD~Ee
linguistic variables. #fb&51
A didactic example is included to illustrate the computational procedure K94bM5O 1
Introduction 引证核心文献,提出假设,指出文章的核心观点 v1p^="IHI
Beginning sfk;c#K
Over the course of the past 30 years, .. has emerged form intuitive |)S*RQb\
We evaluated 508 participants who xtut S
Acute kidney injury (AKI) is associated with an increased incidence of respiratory failure *Tr9pq%m
requiring mechanical ventilation, which greatly increases mortality KxDp+]N]
The cause of respiratory failure in patients with AKI is incompletely understood nO#x"
However, lung injury also occurs after ischemia–reperfusion injury of other organs such /@U bN\
as the liver, gut, and hind limb }s[`T
We have demonstrated previously that qB3E
Given this background, we hypothesized that `1uGU[{x
we demonstrate that R?M>uaxn
Technological revolutions have recently hit the industrial world =MT'e,T
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The development of ... is explored a'A<'(yv
The concept of xx was investigated quite intensively in recent years ;=WwJ Np~
There has been a turning point in ... methodology in accordance with the advent of ... KDb`g}1Q
A major concern in ... today is to continue to improve... 3-'3w ,
It has become increasingly clear that E6z&pM8<8
In this paper, we focus on the need for [s{[
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Our study XlnSh<e
In this paper, we shall first briefly introduce… a ,"
To begin with we will provide a brief background on the $Ggnn#
This will be followed by a description of the xx of the problem and a detailed 20}w.V
presentation of how the required membership functions are defined. UZ#oaD8H6
Details on xx and xx are discussed in later sections. ;e< TEs
Polyphenolic compounds are vasodilators and help to lower the risk of cardiovascular /4@
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diseases. D c;k)z=
Taken together, our novel findings suggest that the EDR induced by the strawberry 4c[/%e:\-
extract was mediated by activation of the PI3 kinase/Akt signaling pathway, resulting in Cy)N hgz
phosphorylation of eNOS. "YWZ&_n**
Objective / Goal / Purpose @DF7j|]tV
The purpose of the inference engine can be outlined as follows: jw
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The ultimate goal of the xx system is to allow the non;experts to utilize the existing jOzi89
knowledge in the area of manual handling of loads, and to provide intelligent, y#th&YC_b
computer;aided instruction for xxx. -y{(h%
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The paper concerns the development of a xx gS8+S\2
The scope of this research lies in - Ry+WS=
The main theme of the paper is the application of rule;based decision making. r)OiiD"
These objectives are to be met with such thoroughness and confidence as to permit ... H5V>d
The objectives of the ... operations study are as follows: F-oe49p5e
The primary purpose/consideration/objective of vB}c6A4'U
The ultimate goal of this concept is to provide IvlfX`("
The main objective of such a ... system is to JgA{1@h
The aim of this paper is to provide methods to construct such probability distribution. j>B* 8*Ss
In order to achieve these objectives, an xx must meet the following requirements: AI Kz]J0;
In order to take advantage of their similarity =5Nh}o(l?
more research is still required before final goal of ... can be completed GM?s8yZ<
In this trial, the objective is to generate... ^g5E&0a`g
for the sake of concentrating on ... research issues {u2Zl7]z^
A major goal of this report is to extend the utilization of a recently developed procedure \$*CXjh3G
for the xx. r-TrA$k
For an illustrative purpose, four well;known OR problems are studied in presence of 4dcm)Xr
fuzzy data: xx. !|UX4
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This illustration points out the need to specify {\CWoFht>
Recent studies have further defined the role of SBP-2 in promoting UGA read-through, c)B3g.C4m
This concept has been further validated with the discovery of patients with impaired V7r_Ubg@K
deiodinase activity due to a mutation in SBP-2 CbC[aVA=
The ultimate goal is both descriptive and prescriptive. u!5q)>Wt(
A wealth of information is to be found in the statistics literature, for example, regarding
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xx ybw\^t
This review will focus on the most recent progress achieved in this field, particularly the , ?U)mYhI
cellular and molecular aspects of local control of thyroid hormone signaling provided by <
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deiodinases. t!*[nfR
A considerable amount of research has been done .. during the last decade 8.n#@%
A great number of studies report on the treatment of uncertainties associated with xx. jwa6
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However, these studies do not provide much attention to undertainty in xx. kN
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well in methodological aspects as in concrete applications. #~)A#~4O
Many research studies have been carried out on this topic. 5X=1a*2']
Problem of xx draw recently more and more attention of system analysis. R20 .dA_N
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Many complex processes unfortunately, do not yield to this design procedure and have, #e-K It
therefore, not yet been automated. \} v@!PQl
Most of the methods developed so far are deterministic and /or probabilistic in nature. @n?"*B
The central issue in all these studies is to KR?aL:RYb
The problem of xx has been studied by other investigators, however, these studies have 5\C(2naf
been based upon classical statistical approaches. [0y,K{8t
Applied ... techniques to or3OLBf* Q
Characterized the ... system as :_6o|9J\t
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Identifies six key issues surrounding high technology <b,WxR`
A comprehensive study of the .. has been undertaken fc@<' -VA
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The system developed by [] consists !9
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A paper relevant to this research was published by [] #oTVfY#
[]'s model requires consideration of .. }C_g;7*
[]' model draws attention to evolution in human development kR
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Though application of xx in the filed of xx has proliferated in recent years, effort in Ne|CWUhO
analyzing xx, especially xx, is lacking. A}9^,C$#
提出Problem / Issue / Question 或假设 >g!$H}\
Unfortunately, real-world engineering problems such as manufacturing planning do not !O!:=wq
fit well with this narrowly defined model. They tend to span broad activities and require b*h:e.q
consideration of multiple aspects. .jP|b~
Remedy / solve / alleviate these problems Vbp
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... is a difficult problem, yet to be adequately resolved I/St=-;
Two major problems have yet to be addressed &?QKWxN
An unanswered question Gq1C"s$4'
This problem in essence involves using x to obtain a solution. J)Yz@0#T(;
An additional research issue to be tackled is .... /PaS<"<P@
Some important issues in developing a ... system are discussed \PN*gDmX
The three prime issues can be summarized: 3+'vNc
The situation leads to the problem of how to determine the ...
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There have been many attempts to #s\yO~F-
It is expected to be serious barrier to 6W YVHG
It offers a simple solution in a limited domain for a complex problem. s7}-j2riq
There are several ways to get around this problem. 3%9XJ]Qao
As difficult as it seems to be, xx is by no means new. L:&