Hallmarks of Cancer: New Dimensions. ypJ".
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast Vmzb
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complexity of cancer phenotypes and genotypes into a provisional set of underly- mxb06u_
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emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- &$`yo`
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- ^$&k5e/}C
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate
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the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added +7t6k7]c
to the roster of functionally important cell types in the tumor microenvironment.