Hallmarks of Cancer: New Dimensions. khAqYu" )
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast t8& q 9$
complexity of cancer phenotypes and genotypes into a provisional set of underly- &!jq!u $(
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have 4 \p -TPM
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- m"4B!S&Fc(
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- 3sFeP &
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate [9V]
On
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added Q2/.6 O8
to the roster of functionally important cell types in the tumor microenvironment.
