肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. awl3|k/  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast x K ;#C  
complexity of cancer phenotypes and genotypes into a provisional set of underly- Tn"^`\m  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have 2GxkOch  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- 6E{(_i  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- %W^Zob  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate !LJ4 S  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added 9/h[
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to the roster of functionally important cell types in the tumor microenvironment.