肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. )n]"~I^  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast 1<Sg @  
complexity of cancer phenotypes and genotypes into a provisional set of underly- /w1M%10   
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have T](}jQxj`  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- ?ac4GA(  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- V2!0),]B  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate ME$J42  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added -V:HT j  
to the roster of functionally important cell types in the tumor microenvironment.