Hallmarks of Cancer: New Dimensions. 3yszf Wr
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast
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complexity of cancer phenotypes and genotypes into a provisional set of underly- P%8
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ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have
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emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- =kp #v
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- V: f z
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate YiJnh 47
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added !trt]? *-
to the roster of functionally important cell types in the tumor microenvironment.
