肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. rd\mFz-SB  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast )_b#c+  
complexity of cancer phenotypes and genotypes into a provisional set of underly- gh}FZs5P  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have YL&$cT]1  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- B_M)<Ad  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram-
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ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate JGSeu
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the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added Kwfrh?  
to the roster of functionally important cell types in the tumor microenvironment.