Hallmarks of Cancer: New Dimensions. 3u%{d G a
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast GfM;saTz{
complexity of cancer phenotypes and genotypes into a provisional set of underly- nUkaz*4qU
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have L^Jk=8
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- ~]ZpA-*@Ut
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- v\(2&*
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate v4@Z(M
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added CI3XzH\IX*
to the roster of functionally important cell types in the tumor microenvironment.
