Hallmarks of Cancer: New Dimensions. SV96eYT<
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast V tr5<:eEx
complexity of cancer phenotypes and genotypes into a provisional set of underly- (}LLk +
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have fbK`A?5K
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- _l;$<]re\k
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- T.p:`}M
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ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate Zm!5X9^!
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added y6S:[Z{~A
to the roster of functionally important cell types in the tumor microenvironment.
