肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. ),)lzN%!  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast OVJ0}5P*  
complexity of cancer phenotypes and genotypes into a provisional set of underly- ~@!bsLSMU  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have j+!v}*I![  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- @7u0v  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- \GBuWY3B  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate >sF)BoLc  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added edD)TpmE,  
to the roster of functionally important cell types in the tumor microenvironment.