Hallmarks of Cancer: New Dimensions. {>n\B~*,"C
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast /m CE=
complexity of cancer phenotypes and genotypes into a provisional set of underly- mL ]a_S{H
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have b ]u01T-
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- I> BGp4 AQ
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- jWqjGX`
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate = 4 wf
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added G_/Dz JBF
to the roster of functionally important cell types in the tumor microenvironment.
