Hallmarks of Cancer: New Dimensions. Q-yNw0V}F
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast Z~;rp`P
complexity of cancer phenotypes and genotypes into a provisional set of underly- Y3H5}4QD
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have }>b@=5O
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- 0~Xt_rN](
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- u Vo"_c w
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate [<wpH0lNoy
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added n.G.f bO
to the roster of functionally important cell types in the tumor microenvironment.
