Hallmarks of Cancer: New Dimensions. (;s \Ip0
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast j6Vuj /+}
complexity of cancer phenotypes and genotypes into a provisional set of underly- 6#.R'O
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have Hiq9Jn uv(
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- pa.W-qyu
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- h5Z%|J>;0
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate YAO.Cc z
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added uD+;5S]us
to the roster of functionally important cell types in the tumor microenvironment.
