Hallmarks of Cancer: New Dimensions. tSDp>0yZ3
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast XSZjuQ<[3
complexity of cancer phenotypes and genotypes into a provisional set of underly- [t^%d 9@t
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have etW-gbr
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- YS"76FJ
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- [0+5 Gx
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate mR{ %f?B
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added BcGQpv &x
to the roster of functionally important cell types in the tumor microenvironment.
