Hallmarks of Cancer: New Dimensions. ]826k pq_
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast x6$3 KDQm
complexity of cancer phenotypes and genotypes into a provisional set of underly- gyPwN
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ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have l_8ibLyo
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- \KS.A
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rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- G{O{
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ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate :6&#u.\u
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added !N_eZPU.v
to the roster of functionally important cell types in the tumor microenvironment.
