Hallmarks of Cancer: New Dimensions. ex~"M&^
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast D0bpD
complexity of cancer phenotypes and genotypes into a provisional set of underly- $;=^|I4E
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have )Z4iM;4]
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- r@i)Sluf
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- 1+3-Z>^ e
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate z7 ?SuJ
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added 80%"2kG
to the roster of functionally important cell types in the tumor microenvironment.
