Hallmarks of Cancer: New Dimensions. uXiN~j &Be
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast \w8\1~#
complexity of cancer phenotypes and genotypes into a provisional set of underly- -Lg
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ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have %a7$QF]
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- x?<FJ"8"k
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- vP,n(reM
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate _#8MkW#]~
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added '5tCz9} Y
to the roster of functionally important cell types in the tumor microenvironment.
