Hallmarks of Cancer: New Dimensions. 0fA42*s;
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast %41dVnWB^4
complexity of cancer phenotypes and genotypes into a provisional set of underly- &[,g `S0
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have .z&V!2zp
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- g0Qg]F5D~
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- !O
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ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate ^tX+<X
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added loN!&YceW
to the roster of functionally important cell types in the tumor microenvironment.
