Hallmarks of Cancer: New Dimensions. &3'II:x(
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast KKl8tI\u~
complexity of cancer phenotypes and genotypes into a provisional set of underly- aZ@Ke$jD
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have J'.U+X U
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- sGc4^Z%l?
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- C$-I DBXK
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate 8lT.2H
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added jun>(7
to the roster of functionally important cell types in the tumor microenvironment.
