Hallmarks of Cancer: New Dimensions. /\0g)B
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The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast ]5Mq^@mD'
complexity of cancer phenotypes and genotypes into a provisional set of underly- C_ 4(- OWq
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have 6I!B>V#U+
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- p]E \!/
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- eN{ewn#0.
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate Hru~Y}V
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added a
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to the roster of functionally important cell types in the tumor microenvironment.
