Hallmarks of Cancer: New Dimensions. ]EHsRd
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast n#6{K6}k~
complexity of cancer phenotypes and genotypes into a provisional set of underly- '1D $ ;
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have ))AxU!*.
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- ND1hZ3(^
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- ,f^fr&6jb
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate QKjn/%l"@
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added n{N0S^h
to the roster of functionally important cell types in the tumor microenvironment.
