Hallmarks of Cancer: New Dimensions. @.p r}S/
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast | I3&a=,
complexity of cancer phenotypes and genotypes into a provisional set of underly- '
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ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have GqgJ ]m
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- "WH
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rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- SRrp
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ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate 0UQ
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the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added 4thPR}DH}
to the roster of functionally important cell types in the tumor microenvironment.
