Hallmarks of Cancer: New Dimensions. CO)b'V,
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast OD@A+"
complexity of cancer phenotypes and genotypes into a provisional set of underly- f}9`iN=k
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have CbvL X="%
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- 4.kkxQR7r
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- D~ `YRbv
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate YU \t+/b
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added /z- C
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to the roster of functionally important cell types in the tumor microenvironment.
