Hallmarks of Cancer: New Dimensions. N"<.v6Z
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast S0 OL;[*.
complexity of cancer phenotypes and genotypes into a provisional set of underly- T}z? i
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have )?OdD7gd
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- UhDf6A `]
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- &\ca ? #
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate u(yN
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the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added )2wf D
to the roster of functionally important cell types in the tumor microenvironment.
