Hallmarks of Cancer: New Dimensions. ~}F$1;t0
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast 2t7Hu)V
complexity of cancer phenotypes and genotypes into a provisional set of underly- Q g;?C
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have X6lR?6u%|
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- ,
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rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- ;wkoQ8FD9
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate 4,pS C
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added drZ1D s
to the roster of functionally important cell types in the tumor microenvironment.
