Hallmarks of Cancer: New Dimensions. p^pQZ6-
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast %fn'iKCB
complexity of cancer phenotypes and genotypes into a provisional set of underly- PT uCN
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have U<ku_(2"#
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- GsP@ B'
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- Hm+6QgCs
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate 9}%~w(P
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added ND9 n1WZ&x
to the roster of functionally important cell types in the tumor microenvironment.
