Hallmarks of Cancer: New Dimensions. !%}n9vr!}\
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast bJ
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complexity of cancer phenotypes and genotypes into a provisional set of underly- 6 8bvbig
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have g i/k#3_m
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- `WCL-OoZc5
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- ct|0zl~
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate |uz<)
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added G na%|tUz|
to the roster of functionally important cell types in the tumor microenvironment.
