Hallmarks of Cancer: New Dimensions. D>wZ0p b-
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast Bo\D. a(T
complexity of cancer phenotypes and genotypes into a provisional set of underly- #2%([w
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have p/]s)uYp$
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- NO>k
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- -)w]a{F
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate F;D1F+S
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added :%-,Fxl 4
to the roster of functionally important cell types in the tumor microenvironment.
